Chemoinformatics: Directions Toward Combating Neglected Diseases

Multivariate Image Analysis Applied to QSAR as a Tool for Mosquitoes Control: Dengue and Yellow Fever

Author(s): Matheus P. Freitas, Teodorico C. Ramalho, Elaine F. F. da Cunha and Rodrigo A. Cormanich

Pp: 154-161 (8)

DOI: 10.2174/978160805183011201010154

* (Excluding Mailing and Handling)


An image-based QSAR approach, called Multivariate Image Analysis Applied to Quantitative Structure-Activity Relationships (MIA-QSAR) is described as a tool to model the toxicities of a series of organotin compounds against Aedes aegypti and Anopheles stephensi mosquito larvae, vectors of dengue and yellow fever. This methodology may help researchers to discover novel, potent mosquito controllers.

Keywords: QSAR-2D, MIA-QSAR, dengue and yellow fever.

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