Nanopharmacology and Nanotoxicology: Clinical Implications and Methods

Advances in Cardiovascular Nanopharmacology

Author(s): Solmaz Maleki Dizaj*, Shahriar Shahi, Khadijeh Khezri and Simin Sharifi

Pp: 28-49 (22)

DOI: 10.2174/9789815079692123010005

* (Excluding Mailing and Handling)


Nanotechnology has caused the most noteworthy influence on oncology, recently. Many nano-based delivery systems for specific medicines and a diversity of other diseases are being advanced nowadays. Nanomedicine is preferably adapted to resolving the main issues of numerous diseases, as it offers the special opportunity to create specific nanoparticles as a carrier for the targeted and controlled transferal of several therapeutic agents to the targeted location. Moreover, ligand-targeting or receptor-mediated targeting methods relate to an extra degree of complexity that may be implemented in the nanoparticles-based product in cardiovascular diseases. Despite the noteworthy increase in studies on the use of nanoparticles in cardiovascular disease, some reports have shown that different types of nanoparticles have cytotoxic action. Future studies are desired to fully investigate toxicity, especially cytotoxicity and inflammatory responses for nanomaterials. The outline of new plans to reduce toxicity should be the aim of future studies. In the present chapter, we emphasize new developments in cardiovascular nanopharmacology and the assistant methods for scheming new nanomaterials for this field. The future lookouts have also been discussed.

Keywords: Cardiovascular diseases, Drug delivery system, Nanotechnology.

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