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Current Chinese Chemistry


ISSN (Print): 2666-0016
ISSN (Online): 2666-0008

Review Article

Synthesis and Biological Activity of Pyrrolizidine Alkaloids: A Review

Author(s): Biswajit Panda*

Volume 3, 2023

Published on: 28 February, 2024

Article ID: e280224227486 Pages: 20

DOI: 10.2174/0126660016269821240215071817

Price: $65


Pyrrolizidine alkaloids (PAs) belong to a structurally varied class of natural products that have garnered significant attention due to their intriguing chemical properties and broad range of biological activities. This review aims to provide a comprehensive overview of the synthesis and biological activity of pyrrolizidine alkaloids. An in-depth exploration of the various synthetic methodologies employed in the construction of these complex molecules, including classical and modern synthetic approaches, is presented in this review. Moreover, the potential therapeutic applications of these alkaloids are discussed, emphasizing their promising role in drug discovery and development. By synthesizing the current knowledge, this paper aims to facilitate further research in the field and inspire the discovery of novel bioactive compounds with therapeutic potential.

Keywords: Natural products, pyrrolizidines, organic synthesis, heterocycles, alkaloids, azabicyclic compounds.

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