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Current Biotechnology


ISSN (Print): 2211-5501
ISSN (Online): 2211-551X

Review Article

Exposure to Endocrine-disrupting Chemicals and Environmental Toxins Attributing to Polycystic Ovarian Syndrome

Author(s): Subrata Mandal, Rukaiah Fatma Begum, Chitra Vellapandian and Sumithra Mohan*

Volume 13, Issue 1, 2024

Published on: 04 January, 2024

Page: [15 - 25] Pages: 11

DOI: 10.2174/0122115501283971231226112856

Price: $65


Polycystic ovary syndrome (PCOS) is a common endocrinopathy characterized by excess androgen and infertility due to anovulatory failure. A significant fraction of the world's population is affected by the infertility condition known as PCOS. Due to the disease's complicated nature and overlapping symptoms, diagnosis of the condition is frequently challenging. Exogenous compounds or combinations known as endocrine-disrupting chemicals (EDCs) can imitate the effects of steroid hormones and obstruct their metabolism. EDCs and this condition have recently been the subject of intensive research to better understand the possible contribution of these substances to the pathophysiology of PCOS. It was shown that EDC exposure can be connected to PCOS in either a direct or indirect way since PCOS is linked to higher levels of oxidative stress and inflammation, which lead to obesity, insulin resistance, and infertility. This review's objective is to investigate how exposure to environmental contaminants affects the etiology of polycystic ovarian syndrome.

Keywords: Endocrine-Disrupting Chemicals (EDCs), Polycystic ovarian syndrome (PCOS), Infertility, Bisphenol A, Phthalates, Persistent organic pollutants (POPs).

Graphical Abstract
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