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Current Chinese Chemistry


ISSN (Print): 2666-0016
ISSN (Online): 2666-0008

Mini-Review Article

Recent Advancements in Multicomponent Reactions of Substituted 2- Aminopyridines Synthesis: A Decade Review

Author(s): Pragati Sharma and Pragya Sinha*

Volume 3, 2023

Published on: 06 December, 2023

Article ID: e061223224235 Pages: 18

DOI: 10.2174/0126660016267259231012105113

Price: $65


One-step synthesis of multifaceted heterocycles employing Multicomponent Reactions (MCRs) corresponds to a viable, innovative, and prospective strategy. In recognition of their noteworthy physiological, biological, and pharmacological behavior, 2-aminopyridines secure an exceptional spot among heterocycles. The current analysis comprises an overview of the scientific literature concerning the multicomponent reactions of substituted 2-aminopyridine synthesis. The stipulated outcomes have been thoroughly categorized according to the number and nature of the components. The past 11 years of literary work (2011–2022) are specifically incorporated. This review article will assist in advancing the development of cutting-edge and enhanced approaches towards the synthesis of 2-aminopyridines and their counterparts.

Keywords: Multicomponent reactions, substituted 2-aminopyridines, medicinal chemistry, malononitrile, enamines, anti-HIV drug.

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