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Current Molecular Medicine


ISSN (Print): 1566-5240
ISSN (Online): 1875-5666


Endothelial Progenitor Cell (EPC) is a Prime Target in Diabetic Wound Healing: Mechanisms and Target Therapies

Author(s): Tanmay Sudhakar Markandeywar, Dilpreet Singh, Gurmeet Singh, Balak Das Kurmi and Raj Kumar Narang*

Volume 24, Issue 9, 2024

Published on: 04 October, 2023

Page: [1073 - 1076] Pages: 4

DOI: 10.2174/1566524023666230911141402

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Xu J, Bai S, Cao Y, et al. miRNA-221-3p in endothelial progenitor cell-derived exosomes accelerates skin wound healing in diabetic mice. Diabetes Metab Syndr Obes 2020; 13: 1259-70.
[] [PMID: 32368119]
Loomans CJM, de Koning EJP, Staal FJT, et al. Endothelial progenitor cell dysfunction: A novel concept in the pathogenesis of vascular complications of type 1 diabetes. Diabetes 2004; 53(1): 195-9.
[] [PMID: 14693715]
Liu ZJ, Velazquez OC. Hyperoxia, endothelial progenitor cell mobilization, and diabetic wound healing. Antioxid Redox Signal 2008; 10(11): 1869-82.
[] [PMID: 18627349]
Georgescu A. Vascular dysfunction in diabetes: The endothelial progenitor cells as new therapeutic strategy. World J Diabetes 2011; 2(6): 92-7.
[] [PMID: 21860692]
Ambasta RK, Kohli H, Kumar P. Multiple therapeutic effect of endothelial progenitor cell regulated by drugs in diabetes and diabetes related disorder. J Transl Med 2017; 15(1): 185.
[] [PMID: 28859673]
Meng S, Cao JT, Zhang B, Zhou Q, Shen CX, Wang CQ. Downregulation of microRNA-126 in endothelial progenitor cells from diabetes patients, impairs their functional properties, via target gene Spred-1. J Mol Cell Cardiol 2012; 53(1): 64-72.
[] [PMID: 22525256]
Brem H, Tomic-Canic M. Cellular and molecular basis of wound healing in diabetes. J Clin Invest 2007; 117(5): 1219-22.
[] [PMID: 17476353]
Wan G, Chen Y, Chen J, et al. Regulation of endothelial progenitor cell functions during hyperglycemia: New therapeutic targets in diabetic wound healing. J Mol Med 2022; 100(4): 485-98.
[] [PMID: 34997250]
Edwards N, Langford-Smith AWW, Wilkinson FL, Alexander MY. Endothelial progenitor cells: New targets for therapeutics for inflammatory conditions with high cardiovascular risk. Front Med 2018; 5: 200.
[] [PMID: 30042945]
Baltzis D, Eleftheriadou I, Veves A. Pathogenesis and treatment of impaired wound healing in diabetes mellitus: New insights. Adv Ther 2014; 31(8): 817-36.
[] [PMID: 25069580]
Moccia F, Tanzi F, Munaron L. Endothelial remodelling and intracellular calcium machinery. Curr Mol Med 2014; 14(4): 457-80.
[] [PMID: 24236452]
Kang H, Ma X, Liu J, Fan Y, Deng X. High glucose–induced endothelial progenitor cell dysfunction. Diab Vasc Dis Res 2017; 14(5): 381-94.
[] [PMID: 28718318]
Kaushik K, Das A. Endothelial progenitor cell therapy for chronic wound tissue regeneration. Cytotherapy 2019; 21(11): 1137-50.
[] [PMID: 31668487]
Di Rocco G, et al. Enhanced healing of diabetic wounds by topical administration of adipose tissue-derived stromal cells overexpressing stromal-derived factor-1: Biodistribution and engraftment analysis by bioluminescent imaging. Stem Cells Int 2010; 2011: 30452.
Kuliszewski MA, Fujii H, Liao C, et al. Molecular imaging of endothelial progenitor cell engraftment using contrast-enhanced ultrasound and targeted microbubbles. Cardiovasc Res 2009; 83(4): 653-62.
[] [PMID: 19564152]
Gaffey AC, Chen MH, Venkataraman CM, et al. Injectable shear-thinning hydrogels used to deliver endothelial progenitor cells, enhance cell engraftment, and improve ischemic myocardium. J Thorac Cardiovasc Surg 2015; 150(5): 1268-77.
[] [PMID: 26293548]
Carenza E, Barceló V, Morancho A, et al. In vitro angiogenic performance and in vivo brain targeting of magnetized endothelial progenitor cells for neurorepair therapies. Nanomedicine 2014; 10(1): 225-34.
[] [PMID: 23792330]
Kim KL, Han DK, Park K, et al. Enhanced dermal wound neovascularization by targeted delivery of endothelial progenitor cells using an RGD-g-PLLA scaffold. Biomaterials 2009; 30(22): 3742-8.
[] [PMID: 19394079]
Gonçalves TAF, Lima VS, de Almeida AJPO, et al. Carvacrol improves vascular function in hypertensive animals by modulating endothelial progenitor cells. Nutrients 2023; 15(13): 3032.
[] [PMID: 37447358]
Yuan J, Wang Y, Wang D, Yan H, Wang N. Loxenatide attenuates ROS-mediated vascular endothelial progenitor cell damage and mitochondrial dysfunction via SIRT3/Foxo3 signaling pathway. J Biochem Mol Toxicol 2023; e23452.
[] [PMID: 37417536]
Hu L, Dai SC, Luan X, Chen J, Cannavicci A. Dysfunction and therapeutic potential of endothelial progenitor cells in diabetes mellitus. J Clin Med Res 2018; 10(10): 752-7.
[] [PMID: 30214646]
Kolluru GK, Bir SC, Kevil CG. Endothelial dysfunction and diabetes: Effects on angiogenesis, vascular remodeling, and wound healing. Int J Vasc Med 2012; 2012: 91826.
Tousoulis D, Papageorgiou N, Androulakis E, et al. Diabetes mellitus-associated vascular impairment: Novel circulating biomarkers and therapeutic approaches. J Am Coll Cardiol 2013; 62(8): 667-76.
[] [PMID: 23948511]

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