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Mini-Reviews in Organic Chemistry


ISSN (Print): 1570-193X
ISSN (Online): 1875-6298

Mini-Review Article

Recent Advances in Total Synthesis of Tetrahydroisoquinoline Alkaloids Quinocarcin and Lemonomycin

Author(s): Ju Guo*, Yang Yang, Lanhua Shen, Jingyi Li, Fuan Li and Sifan Wang

Volume 21, Issue 8, 2024

Published on: 19 September, 2023

Page: [852 - 861] Pages: 10

DOI: 10.2174/1570193X20666230801101427

Price: $65


Tetrahydroisoquinoline natural products are a kind of alkaloids containing various pharmacological activities. These structurally diverse alkaloids mainly consist of two subclasses, monotetrahydroisoquinolines (MTHI) and bistetrahydroisoquinolines (BTHI). Since its family member, Ecteinascidin-743 (INN: Trabectedin, trade name: Yondelis®), has been approved by European Union in 2007 and the FDA in 2015 for the treatment of advanced soft tissue tumors, the research on this kind of natural product is full of new vitality. Quinocarcin and lemonomycin share a common diazabicyclo[3.2.1]octane framework that belongs to the subclass of MTHI, and their excellent antitumor activity and challenging architecture have made them an ideal target for total synthesis. In this short review, the progress in the total synthesis of quinocarcin and lemonomycin is summarized.

Keywords: Tetrahydroisoquinoline alkaloid, monotetrahydroisoquinolines, bistetrahydroisoquinolines, total synthesis, quinocarcin, lemonomycin

Graphical Abstract
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