Generic placeholder image

Current Molecular Medicine


ISSN (Print): 1566-5240
ISSN (Online): 1875-5666

Review Article

Several Applications of Solid Lipid Nanoparticles in Drug Delivery

Author(s): Noor Hassan Sulaiman Khil, Shaweta Sharma*, Pramod Kumar Sharma and Aftab Alam

Volume 24, Issue 9, 2024

Published on: 18 September, 2023

Page: [1077 - 1090] Pages: 14

DOI: 10.2174/1566524023666230720110351

Price: $65


Rapid progress is being made in the area of nanotechnology; solid lipid nanoparticles are currently at the forefront of research and development. They have the capability of becoming employed in an extensive number of applications, including the delivery of medications, clinical treatment, and research, in addition to uses in other areas of academic inquiry that could benefit from their utilisation. This article presents a thorough analysis of solid lipid nanoparticles, covering subjects such as their goals, preparation strategy, applications, advantages, and possible remedies for the issues that have been raised. This review provides a discussion of solid lipids that is both in-depth and comprehensive. Studies that investigate the manner in which SLNs are prepared and the routes via which they are administered are typical. Aspects concerning the route of administration of SLNs as well as the destiny of the carriers in vivo are also investigated in this paper.

Keywords: Nanotechnology, solid lipid nanoparticle (SLNs), carriers for SLNs, patents of SLNs, application of SLNs.

Paliwal R, Rai S, Vaidya B, et al. Effect of lipid core material on characteristics of solid lipid nanoparticles designed for oral lymphatic delivery. Nanomedicine 2009; 5(2): 184-91.
[] [PMID: 19095502]
Cortesi R, Esposjto E, Luca G, Nastruzzi C. Production of lipospheres as carriers for bioactive compounds. Biomaterials 2002; 23(11): 2283-94.
[] [PMID: 12013175]
Scheffel U, Rhodes BA, Natarajan TK, Wagner HN Jr. Albumin microspheres for study of the reticuloendothelial system. J Nucl Med 1972; 13(7): 498-503.
[PMID: 5033902]
Hanumanaik M, Patel SK, Sree KR. Solid lipid nanoparticles: A review. Int J Pharm Sci Res 2013; 4(3): 928-40.
Silva AC, González-Mira E, García ML, et al. Preparation, characterization and biocompatibility studies on risperidone-loaded Solid Lipid Nanoparticles (SLN): High pressure homogenization versus ultrasound. Colloids Surf B Biointerfaces 2011; 86(1): 158-65.
[] [PMID: 21530187]
Manjunath K, Reddy JS, Venkateswarlu V. Solid lipid nanoparticles as drug delivery systems. Methods Find Exp Clin Pharmacol 2005; 27(2): 127-44.
[] [PMID: 15834465]
Sathali AH, Ekambaram P, Priyanka K. Solid lipid nanoparticles: A review. Sci Rev Chem Commun 2012; 2(1): 80-102.
Das S, Chaudhury A. Recent advances in lipid nanoparticle formulations with solid matrix for oral drug delivery. AAPS PharmSciTech 2011; 12(1): 62-76.
[] [PMID: 21174180]
Gasco M, Saettone M, Zara G. Pharmaceutical compositions suitable for the treatment of ophthalmic diseases. United States Patent Application US 10/533,512, 2006.
Xu B, Wang Y, Zheng J. Cucurbitacin solid lipid nanoparticle preparation and preparation method thereof. CN Patent 200910065523, 2009.
Shi J, Zhang T. Aripiprazole injection and preparation method therefore. CN Patent 201610002634, 2016.
Jin Yu. Solid lipid nanoparticles composition for skin whitening effect comprising MHY498 and preparation method thereof. KR Patent 101860555B1, 2016.
Repka MA, Patil HG, Majumdar S, Park J, Kulkarni VI. >Systems and methods for preparing solid lipid nanoparticles. US Patent 20170172937A1, 2017.
Park SM, Kim HR, Park JC, Chae SY. Solid lipid nanoparticles including elastin-like polypeptides and use thereof. United States US Patent application 20130197359A1, 2013.
Krysztof CA. Solid lipid nanoparticles of roxithromycin for hair loss or acne. EP Patent 2919756A1, 2014.
Marina GA, Elena P, Battaglia LS. Method for preparing solid lipid nanoparticles containing antibodies in ion pair form using the fatty acid coacervation technique. WO Patent 2015007398A1, 2015.
Li Y, Chen L, Gu W. Long-circulating solid lipid docetaxel nanoparticles and preparation method thereof. CN Patent 200810041865, 2008.
Kneuer C, Lehr CM, Olbrich C, Müller RH. Transfection complexes (Transoplex) having a reduced toxicity, a higher physical stability, and a higher transfection efficiency, and a method for the production thereof. WO Patent 02051446, 2002.
Reddy AP, Parthiban S, Vikneswari A, Senthilkumar GP. A modern review on solid lipid nanoparticles as novel controlled drug delivery system. Int J Res Pharm Nano Sci 2014; 3(4): 313-25.
Garud A, Singh D, Garud N. Solid Lipid Nanoparticles (SLN): Method, characterization and applications. Int Curr Pharm J 2012; 1(11): 384-93.
Mehnert W, Mäder K. Solid lipid nanoparticles. Adv Drug Deliv Rev 2012; 64: 83-101.
[] [PMID: 11311991]
Yadav P, Soni G, Mahor A, Alok S, Singh PP, Verma A. Solid lipid nanoparticles: An effective and promising drug delivery system-A review. Int J Pharm Sci Res 2014; 5(4): 1152.
Üner M, Yener G. Importance of solid lipid nanoparticles (SLN) in various administration routes and future perspectives. Int J Nanomedicine 2007; 2(3): 289-300.
[PMID: 18019829]
Patil-Gadhe A, Kyadarkunte A, Patole M, Pokharkar V. Montelukast-loaded nanostructured lipid carriers: Part II Pulmonary drug delivery and in vivo in vivo aerosol performance. Eur J Pharm Biopharm 2014; 88(1): 169-77.
[] [PMID: 25078860]
Paranjpe M, Müller-Goymann C. Nanoparticle-mediated pulmonary drug delivery: A review. Int J Mol Sci 2014; 15(4): 5852-73.
[] [PMID: 24717409]
Muller RH, Runge SA. Solid lipid nanoparticles (SLN) for controlled drug delivery. In: Submicron emulsions in drug targeting and delivery. Oxfordshire: UK: Routledge taylor and francis group 1998; pp. 219-34.
Mishra V, Bansal K, Verma A, et al. Solid lipid nanoparticles: Emerging colloidal nano drug delivery systems. Pharmaceutics 2018; 10(4): 191.
[] [PMID: 30340327]
Mukherjee S, Ray S, Thakur RS. Solid lipid nanoparticles: A modern formulation approach in drug delivery system. Indian J Pharm Sci 2009; 71(4): 349-58.
[] [PMID: 20502539]
Parhi R, Suresh P. Preparation and characterization of solid lipid nanoparticles-a review. Curr Drug Discov Technol 2012; 9(1): 2-16.
[] [PMID: 22235925]
Souto EB, Wissing SA, Barbosa CM, Müller RH. Development of a controlled release formulation based on SLN and NLC for topical clotrimazole delivery. Int J Pharm 2004; 278(1): 71-7.
[] [PMID: 15158950]
Pardeike J, Hommoss A, Müller RH. Lipid nanoparticles (SLN, NLC) in cosmetic and pharmaceutical dermal products. Int J Pharm 2009; 366(1-2): 170-84.
[] [PMID: 18992314]
Naguib YW, Rodriguez BL, Li X, Hursting SD, Williams RO III, Cui Z. Solid lipid nanoparticle formulations of docetaxel prepared with high melting point triglycerides: in vivo and in vivo evaluation. Mol Pharm 2014; 11(4): 1239-49.
[] [PMID: 24621456]
Gasco MR. Method for producing solid lipid microspheres having a narrow size distribution. US Patent 5,250,236, 1993.
Venkateswarlu V, Manjunath K. Preparation, characterization and in vivo release kinetics of clozapine solid lipid nanoparticles. J Control Release 2004; 95(3): 627-38.
[] [PMID: 15023472]
Hu FQ, Yuan H, Zhang HH, Fang M. Preparation of solid lipid nanoparticles with clobetasol propionate by a novel solvent diffusion method in aqueous system and physicochemical characterization. Int J Pharm 2002; 239(1-2): 121-8.
[] [PMID: 12052697]
Trotta M, Debernardi F, Caputo O. Preparation of solid lipid nanoparticles by a solvent emulsification–diffusion technique. Int J Pharm 2003; 257(1-2): 153-60.
[] [PMID: 12711170]
Yuan H, Huang LF, Du YZ, et al. Solid lipid nanoparticles prepared by solvent diffusion method in a nanoreactor system. Colloids Surf B Biointerfaces 2008; 61(2): 132-7.
[] [PMID: 17888636]
Kaiser CS, Rompp H. Pharmaceutical application of supercritical carbon dioxide. Pharmazie 2001; 56: 907-26.
Svilenov H, Tzachev C. Solid lipid nanoparticles—a promising drug delivery system. Nanomedicine 2014; 2: 187-237.
Charcosset C, El-Harati A, Fessi H. Preparation of solid lipid nanoparticles using a membrane contactor. J Control Release 2005; 108(1): 112-20.
[] [PMID: 16169111]
Schubert M, Müller-Goymann CC. Solvent injection as a new approach for manufacturing lipid nanoparticles – evaluation of the method and process parameters. Eur J Pharm Biopharm 2003; 55(1): 125-31.
[] [PMID: 12551713]
Luo Y, Chen D, Ren L, Zhao X, Qin J. Solid lipid nanoparticles for enhancing vinpocetine’s oral bioavailability. J Control Release 2006; 114(1): 53-9.
[] [PMID: 16828192]
García-Fuentes M, Torres D, Alonso MJ. Design of lipid nanoparticles for the oral delivery of hydrophilic macromolecules. Colloids Surf B Biointerfaces 2003; 27(2-3): 159-68.
Utada AS, Lorenceau E, Link DR, Kaplan PD, Stone HA, Weitz DA. Monodisperse double emulsions generated from a microcapillary device. Science 2005; 308(5721): 537-41.
[] [PMID: 15845850]
Liu J, Gong T, Wang C, Zhong Z, Zhang Z. Solid lipid nanoparticles loaded with insulin by sodium cholate-phosphatidylcholine-based mixed micelles: Preparation and characterization. Int J Pharm 2007; 340(1-2): 153-62.
[] [PMID: 17428627]
Liu J, Gong T, Fu H, et al. Solid lipid nanoparticles for pulmonary delivery of insulin. Int J Pharm 2008; 356(1-2): 333-44.
[] [PMID: 18281169]
Reithmeier H, Herrmann J, Göpferich A. Development and characterization of lipid microparticles as a drug carrier for somatostatin. Int J Pharm 2001; 218(1-2): 133-43.
[] [PMID: 11337157]
Zhang S, Yun J, Shen S, et al. Formation of solid lipid nanoparticles in a microchannel system with a cross-shaped junction. Chem Eng Sci 2008; 63(23): 5600-5.
Zhang S, Shen S, Chen Z, et al. Preparation of solid lipid nanoparticles in co-flowing microchannels. Chem Eng J 2008; 144(2): 324-8.
Müller RH, Mehnert W, Lucks JS, Schwarz C, Zur Mühlen A, Meyhers H. Solid Lipid Nanoparticles (SLN): An alternative colloidal carrier system for controlled drug delivery. Eur J Pharm Biopharm 1995; 41(1): 62-9.
Freitas C, Müller RH. Spray-drying of solid lipid nanoparticles (SLNTM). Eur J Pharm Biopharm 1998; 46(2): 145-51.
[] [PMID: 9795036]
Sharma G, Ballauff M. Cationic spherical polyelectrolyte brushes as nanoreactors for the generation of gold particles. Macromol Rapid Commun 2004; 25(4): 547-52.
Ohshima H, Miyagishima A, Kurita T, et al. Freeze-dried nifedipine-lipid nanoparticles with long-term nano-dispersion stability after reconstitution. Int J Pharm 2009; 377(1-2): 180-4.
[] [PMID: 19446623]
Subedi RK, Kang KW, Choi HK. Preparation and characterization of solid lipid nanoparticles loaded with doxorubicin. Eur J Pharm Sci 2009; 37(3-4): 508-13.
[] [PMID: 19406231]
Dong X, Mattingly CA, Tseng M, Cho M, Adams VR, Mumper RJ. Development of new lipid-based paclitaxel nanoparticles using sequential simplex optimization. Eur J Pharm Biopharm 2009; 72(1): 9-17.
[] [PMID: 19111929]
Sinha VR, Srivastava S, Goel H, Jindal V. Solid lipid nanoparticles (SLN’S)-trends and implications in drug targeting. Int J Adv Pharmaceut Sci 2010; 1(3): 212-38.
Negi JS, Chattopadhyay P, Sharma AK, Ram V. Development of solid lipid nanoparticles (SLNs) of lopinavir using hot self nano-emulsification (SNE) technique. Eur J Pharm Sci 2013; 48(1-2): 231-9.
[] [PMID: 23153618]
Silva AC, Kumar A, Wild W, Ferreira D, Santos D, Forbes B. Long-term stability, biocompatibility and oral delivery potential of risperidone-loaded solid lipid nanoparticles. Int J Pharm 2012; 436(1-2): 798-805.
[] [PMID: 22867992]
Singh H, Bhandari R, Kaur IP. Encapsulation of Rifampicin in a solid lipid nanoparticulate system to limit its degradation and interaction with Isoniazid at acidic pH. Int J Pharm 2013; 446(1-2): 106-11.
[] [PMID: 23410991]
Dudhipala N, Janga KY, Gorre T. Comparative study of nisoldipine-loaded nanostructured lipid carriers and solid lipid nanoparticles for oral delivery: Preparation, characterization, permeation and pharmacokinetic evaluation. Artif Cells Nanomed Biotechnol 2018; 46(S2): 616-25.
Yang SC, Lu LF, Cai Y, Zhu JB, Liang BW, Yang CZ. Body distribution in mice of intravenously injected camptothecin solid lipid nanoparticles and targeting effect on brain. J Control Release 1999; 59(3): 299-307.
[] [PMID: 10332062]
Zur Mühlen A, Mehnert W. Drug release and release mechanism of prednisolone loaded solid lipid nanoparticles. Pharmazie 1998; 53(8): 552-5.
Bhaskar K, Anbu J, Ravichandiran V, Venkateswarlu V, Rao Y. Lipid nanoparticles for transdermal delivery of flurbiprofen: Formulation, in vivo, ex vivo and in vivo studies. Lipids Health Dis 2009; 8(1): 6.
[] [PMID: 19243632]
Yadav N, Khatak S. And Singh, S., “Solid Lipid Nanoparticles A Review”. Int J App Pharmaceut 2013; 5(2): 8-18.
Souto EB, Müller RH. Lipid nanoparticles: Effect on bioavailability and pharmacokinetic changes. Handbook of Experimental Pharmacology. Berlin/Heidelberg, Germany: Springer-Verlag 2010; 197: pp. 115-41.
Gokce EH, Sandri G, Bonferoni MC, et al. Cyclosporine A loaded SLNs: Evaluation of cellular uptake and corneal cytotoxicity. Int J Pharm 2008; 364(1): 76-86.
[] [PMID: 18725276]
Lai JY. Biocompatibility of chemically cross-linked gelatin hydrogels for ophthalmic use. J Mater Sci Mater Med 2010; 21(6): 1899-911.
[] [PMID: 20238149]
Khurana LK, Singh R, Singh H, Sharma M. Systematic development and optimization of an in-situ gelling system for moxifloxacin ocular nanosuspension using high-pressure homogenization with an improved encapsulation efficiency. Curr Pharm Des 2018; 24(13): 1434-45.
[] [PMID: 29611480]
Araújo J, Gonzalez E, Egea MA, Garcia ML, Souto EB. Nanomedicines for ocular NSAIDs: Safety on drug delivery. Nanomedicine 2009; 5(4): 394-401.
[] [PMID: 19341814]
Sznitowska M, Janicki S, Dabrowska EA, Gajewska M. Physicochemical screening of antimicrobial agents as potential preservatives for submicron emulsions. Eur J Pharm Sci 2002; 15(5): 489-95.
[] [PMID: 12036725]
Sznitowska M, Zurowska-Pryczkowska K, Dabrowska E, Janicki S. Increased partitioning of pilocarpine to the oily phase of submicron emulsion does not result in improved ocular bioavailability. Int J Pharm 2000; 202(1-2): 161-4.
[] [PMID: 10915939]
Sanap G, Mohanta GA. Review: Solid lipid nanoparticle a potential drug delivery carrier. Int J Chem Pharm Anal 2014; 1(2)
Müller RH, Radtke M, Wissing SA. Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations. Adv Drug Deliv Rev 2002; 54(S1): S131-55.
[] [PMID: 12460720]
Mei Z, Wu Q, Hu S, Lib X, Yang X. Triptolide loaded solid lipid nanoparticle hydrogel for topical application. Drug Dev Ind Pharm 2005; 31(2): 161-8.
[] [PMID: 15773283]
Souto EB, Müller RH. The use of SLN and NLC as topical particulate carriers for imidazole antifungal agents. Pharmazie 2006; 61(5): 431-7.
[PMID: 16724541]
Chen H, Chang X, Du D, et al. Podophyllotoxin-loaded solid lipid nanoparticles for epidermal targeting. J Control Release 2006; 110(2): 296-306.
[] [PMID: 16325954]
Jenning V, Schäfer-Korting M, Gohla S. Vitamin A-loaded solid lipid nanoparticles for topical use: Drug release properties. J Control Release 2000; 66(2-3): 115-26.
[] [PMID: 10742573]
Liu J, Hu W, Chen H, Ni Q, Xu H, Yang X. Isotretinoin-loaded solid lipid nanoparticles with skin targeting for topical delivery. Int J Pharm 2007; 328(2): 191-5.
[] [PMID: 16978810]
Choi M, Kim J, Maibach H. Topical DNA vaccination with DNA/Lipid based complex. Curr Drug Deliv 2006; 3(1): 37-45.
[] [PMID: 16472092]
Jain SK, Chourasia MK, Masuriha R, et al. Solid lipid nanoparticles bearing flurbiprofen for transdermal delivery. Drug Deliv 2005; 12(4): 207-15.
[] [PMID: 16036715]
Santos Maia C, Mehnert W, Schaller M, et al. Drug targeting by solid lipid nanoparticles for dermal use. J Drug Target 2002; 10(6): 489-95.
[] [PMID: 12575739]
Wissing SA, Müller RH. Solid lipid nanoparticles (SLN)--a novel carrier for UV blockers. Pharmazie 2001; 56(10): 783-6.
[PMID: 11683123]
Aldayel AM, O’Mary HL, Valdes SA, et al. Lipid nanoparticles with minimum burst release of TNF-α siRNA show strong activity against rheumatoid arthritis unresponsive to methotrexate. J Control Release 2018; 283: 280-9.
[] [PMID: 29859232]
Khosa A, Reddi S, Saha RN. Nanostructured lipid carriers for site-specific drug delivery. Biomed Pharmacother 2018; 103: 598-613.
[] [PMID: 29677547]
Shenoy VS, Vijay IK, Murthy RSR. Tumour targeting: Biological factors and formulation advances in injectable lipid nanoparticles. J Pharm Pharmacol 2010; 57(4): 411-21.
[] [PMID: 15831200]
Murthy RS. Solid lipid nanoparticles as carriers for anti-cancer drugs to solid tumours. Drug Deliv 2005; 12: 385-92.
Ruckmani K, Sivakumar M, Ganeshkumar PA. Methotrexate loaded solid lipid nanoparticles (SLN) for effective treatment of carcinoma. J Nanosci Nanotechnol 2006; 6(9): 2991-5.
[] [PMID: 17048509]
Kang KW, Chun MK, Kim O, et al. Doxorubicin-loaded solid lipid nanoparticles to overcome multidrug resistance in cancer therapy. Nanomedicine 2010; 6(2): 210-3.
[] [PMID: 20060074]
da Rocha MCO, da Silva PB, Radicchi MA, et al. Docetaxel-loaded solid lipid nanoparticles prevent tumor growth and lung metastasis of 4T1 murine mammary carcinoma cells. J Nanobiotechnology 2020; 18(1): 43.
[] [PMID: 32164731]
Abbas H, Refai H, El Sayed N. Superparamagnetic iron oxide–loaded lipid nanocarriers incorporated in thermosensitive in situ gel for magnetic brain targeting of clonazepam. J Pharm Sci 2018; 107(8): 2119-27.
[] [PMID: 29665379]
Jenning V, Gysler A, Schäfer-Korting M, Gohla SH. Vitamin A loaded solid lipid nanoparticles for topical use: Occlusive properties and drug targeting to the upper skin. Eur J Pharm Biopharm 2000; 49(3): 211-8.
[] [PMID: 10799811]
Patil K, Bagade S, Bonde S, Sharma S, Saraogi G. Recent therapeutic approaches for the management of tuberculosis: Challenges and opportunities. Biomed Pharmacother 2018; 99: 735-45.
[] [PMID: 29710471]
Castellani S, Trapani A, Spagnoletta A, et al. Nanoparticle delivery of grape seed-derived proanthocyanidins to airway epithelial cells dampens oxidative stress and inflammation. J Transl Med 2018; 16(1): 140.
[] [PMID: 29792199]
Choi KO, Aditya NP, Ko S. Effect of aqueous pH and electrolyte concentration on structure, stability and flow behavior of non-ionic surfactant based solid lipid nanoparticles. Food Chem 2014; 147: 239-44.
[] [PMID: 24206712]
Hu F, Hong Y, Yuan H. Preparation and characterization of solid lipid nanoparticles containing peptide. Int J Pharm 2004; 273(1-2): 29-35.
[] [PMID: 15010127]
Gomes FLT, Maranhão RC, Tavares ER, et al. Regression of atherosclerotic plaques of cholesterol-fed rabbits by combined chemotherapy with paclitaxel and methotrexate carried in lipid core nanoparticles. J Cardiovasc Pharmacol Ther 2018; 23(6): 561-9.
[] [PMID: 29779420]
Vicente-Pascual M, Albano A, Solinís MÁ, et al. Gene delivery in the cornea: in vivo & ex vivo evaluation of solid lipid nanoparticle-based vectors. Nanomedicine 2018; 13(15): 1847-54.
[] [PMID: 29792369]
Lakshminarayanan R, Ye E, Young DJ, Li Z, Loh XJ. Recent advances in the development of antimicrobial nanoparticles for combating resistant pathogens. Adv Healthc Mater 2018; 7(13): 1701400.
[] [PMID: 29717819]
Lai F, Wissing SA, Müller RH, Fadda AM. Artemisia arborescens L essential oil-loaded solid lipid nanoparticles for potential agricultural application: Preparation and characterization. AAPS PharmSciTech 2006; 7(1): E10-8.
[] [PMID: 16584150]
Lippacher A, Müller RH, Mäder K. Investigation on the viscoelastic properties of lipid based colloidal drug carriers. Int J Pharm 2000; 196(2): 227-30.
[] [PMID: 10699724]

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy