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Current Molecular Medicine

Editor-in-Chief

ISSN (Print): 1566-5240
ISSN (Online): 1875-5666

Review Article

The Role and Application of Fibroblast Activating Protein

Author(s): Xiao-lou Zhang, Wang Xiao, Jian-ping Qian, Wan-jun Yang, Hao Xu, Xing-da Xu and Guo-wei Zhang*

Volume 24, Issue 9, 2024

Published on: 26 September, 2023

Page: [1097 - 1110] Pages: 14

DOI: 10.2174/1566524023666230530095305

Price: $65

Abstract

Fibroblast activation protein-α (FAP), a type-II transmembrane serine protease, is rarely expressed in normal tissues but highly abundant in pathological diseases, including fibrosis, arthritis, and cancer. Ever since its discovery, we have deciphered its structure and biological properties and continue to investigate its roles in various diseases while attempting to utilize it for targeted therapy. To date, no significant breakthroughs have been made in terms of efficacy. However, in recent years, several practical applications in the realm of imaging diagnosis have been discovered. Given its unique expression in a diverse array of pathological tissues, the fundamental biological characteristics of FAP render it a crucial target for disease diagnosis and immunotherapy. To obtain a more comprehensive understanding of the research progress of FAP, its biological characteristics, involvement in diseases, and recent targeted application research have been reviewed. Moreover, we explored its development trend in the direction of clinical diagnoses and treatment.

Keywords: Fibroblast activated protein, FAPI, fibroblasts, biomarker, targeted therapy, immunotherapy.

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